Waddington’s Epigenetic Landscape

This is a print from our collection of photographic and illustrative material from Waddington’s publications. It illustrates the epigenetic landscape, the concept for which Waddington is perhaps best remembered. This image first appeared in Waddington’s book The Strategy of the Genes (Allen and Unwin, 1957) and visualises the developmental history of a cell in an embryo, represented here by a ball rolling down the ‘landscape’. As it rolls, the ball has several ‘choices’ as to which way to go – just as the developing embryo is influenced down certain ‘paths’ by various genetic and environmental factors – and by the time it reaches the bottom of the landscape, it will have made several such ‘choices’. Waddington called the pathways which are permitted ‘chreodes’ (described as ‘the path followed by a homing missile, which finds its way to a stationary target’). The underlying concept is that the entire ‘landscape’ of development is influenced by the actions and pathways of each individual gene, and also that development can even be disturbed (ie by the ball being pushed up a ridge) and yet still reach an normalised equilibrium (the bottom of the ‘valley’) before the adult state is reached.

In The Strategy of the Genes, Waddington states that although the epigenetic landscape ‘only provides a rough and ready picture of the developing embryo, and cannot be interpreted rigorously, it has certain merits for those who, like myself, find it comforting to have some mental picture, however vague, for what they are trying to think about.’ Quite! Waddington’s epigenetic landscape is as influential a concept – and diagram – today as it ever was, and part of its effectiveness relies on Waddington’s ability to describe a complex idea using clear language and striking visuals.

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‘Dolly’ in Broadsheet

We are delighted to see our article about the progress of ‘Towards Dolly’ in the latest issue of the Scottish Council on Archives’ magazine Broadsheet!

 The patterns on the page are details from a drawing made by Waddington from his 1923 essay ‘Alchemy’ from his school days (see below). I especially like the way that these patterns have been made to look almost psychedelic in the article!

You can read the full edition of SCA Broadsheet here

 

 

Hello Dolly!

Welcome to the first blog post from the ‘Towards Dolly’ project! The Project Archivist and Rare Books Cataloguer have now begun cataloguing the important genetics collections held by Edinburgh University Library in the Centre for Research Collections and over the coming months we will keep you updated about our progress and share any interesting and unusual items we come across.

You can read more about the project in the About Us part of this blog.